Chiral vinylphosphonate and phosphonate analogues of the immunosuppressive agent FTY720.
نویسندگان
چکیده
The first enantioselective synthesis of chiral isosteric phosphonate analogues of FTY720 is described. One of these analogues, FTY720-(E)-vinylphosphonate (S)-5, but not its R enantiomer, elicited a potent antiapoptotic effect in intestinal epithelial cells, suggesting that it exerts its action via the enantioselective activation of a receptor. (S)-5 failed to activate the sphingosine 1-phosphate type 1 (S1P(1)) receptor.
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عنوان ژورنال:
- The Journal of organic chemistry
دوره 74 8 شماره
صفحات -
تاریخ انتشار 2009